Freedom, from a neuron’s point of view

August 22, 2013 at 1:43 pm | Posted in Uncategorized | 3 Comments
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Like any well-meaning science communicator, I’m on the lookout for new ways to communicate about my favourite topic, neuroscience.

Thalamus small view

The location of the thalamus (in red) in the human brain. Image is by Life Science Databases (LSDB). (CC-BY-SA-2.1-jp (http://creativecommons.org/licenses/by-sa/2.1/jp/deed.en)), via Wikimedia Commons.

Images, like the view of the thalamus shown here, look great, but they need words, or a lot of background knowledge, to communicate their meaning.

So it’s back to words. But what kind of words? Well, it’s said that fiction’s a good way of communicating … in some cases anyway!

I’m not too keen on the idea that science is science and should steer well clear of anything that smacks of the humanities. People have quite enough tricks for emphasizing their differences, and feeling superior in consequence, without barricading intellectual endeavours into disciplinary silos. (I know, I know, talk about championing a lost cause!) Besides, neuroscientists are happy to use the visual arts to put their work across, so why not other art forms?

All fiction is in a sense concerned with brains’ activities, but not many authors have tried writing fiction about brains themselves. Pondering this one day, I thought: “Someone should write a short story about brains! I’d read it! Probably.” Then I went back to reading whatever exciting science article had just fallen out of my inbox and onto my to-do list.

Some time later this short story wandered into my brain. It made me smile, so I caught the thing and submitted it to a writing competition (Writers and Artists) on the theme of ‘freedom’, where, to my astonishment, it was short-listed. You can download it as a PDF here (‘Freedom’, by Neurotaylor). I’m posting it on this blog as an exercise in alternative methods of science communication.

And If you know of any great fiction about brains themselves, let me know.

Here’s the story, set out as a taster so the post isn’t too long. The whole thing’s around 2000 words.

***********************************************************************************

Freedom

Alright mate? You on the tour? Welcome to the department. I’m Alfie.

Ever been inside a brain before? No? That’s unusual, not many people start their visit here.

Fully booked, eh? Don’t apologise, mate, we’re used to it. People wanna see the bits they’ve heard of. It’s all, “Ooh, can we go to the prefrontal cortex?”, like that’s the only department that matters. I tell you, mate, without us those guys in prefrontal would be twiddling their dendrites and rotting.

Yeah, they don’t half play up to it though. You’ll see ‘em later. All that, “Oh yes, it’s a great responsibility”, and banging on about their dopamine levels, as if the rest of us never get a sniff of dopamine. They don’t half try it on, that lot. They’re just passing messages, same as the rest of us.

Load of posers, if you ask me. Don’t tell ‘em I said that.

Anyway, welcome to the Thalamus Department. Here in the LGN section –

[read on]

Sorry, mate. Lateral geniculate nucleus. Bit of a mouthful.

Geniculate, yeah.

Dunno, that’s just how it is. Anyway, come and meet some of the gang. Alan, Albert, Alec, Fred, Algie, Alistair, say hi. And this is Sue.

Yeah, we’re neurons, she’s an interneuron.

That means we pass messages – yeah, to them upstairs mainly – and she keeps us from getting overexcited, don’t you love? Soothes us down, tells us when to cool it. Rules us with a rod of iron, does Sue.

Upstairs? Blimey, mate, you didn’t get the briefing, did you? Visual cortex, that’s our output department, where we send the goods.

Yeah, they come in here, we process ‘em and send ‘em on. Each of us is in charge of a group of retinals, see.

Retinals? Retinal cells, mate. In the eyes. The frontliners, the ones that turn light into messages.

Blimey, I wouldn’t say that in front of them. They reckon they’re the ones who do the proper work, the rest of us are just bloody bureaucrats.

Anyway, they report to us through those synapses there.

Yeah, on our dendrites. You got it. We process the messages …

How? How long have you got, mate?

Yeah, course I could tell you, it’s not like it’s classified. Just gets a bit technical for most people.

Right. So we process it, shovel it into our axons – yeah, these long things here – send it on, and deal with any feedback from up above.

All the time, mate. Never stops, I tell you. I’m on special dispensation here, the other lads are covering my retinals. We take it in turns, see, the guidebook bit.

Food? Eat on the job, mate, direct from the blood supply. Yeah, like I told you, it’s 24/7 here. Slackens off a bit once the eyelids come down, but even then we’ve still got stuff to do.

Holidays? You what? We’re neurons, mate.

Well, we’re all doing similar stuff, but each of us gets different inputs. It depends on your retinals. Me, I like vertical stripes best, but I’ll take spots, splodges, whatever really.

Colour? Nah, you want the parvo lot for that, next door.

Parvocellular. Cos they’re titchy bastards, unlike us magnos. Magno means big, see, parvo means small. Us big cells, we handle shapes and movement. Colour, that’s fancy stuff, the parvos deal with that.

Nah, we’re all pretty friendly here. Been doing it for years, see. Makes for, whatcha call it, camaraderie. Now, if you’re talking about upstairs, or downstairs for that matter, that’s different. Here in the thalamus we’re stuck in the middle, so we get it in the soma from both ends.

I mentioned feedback from upstairs, did I? Feedback! They never stop whingeing. Filter this, amplify that, too much noise, too quiet … Don’t half give us the runaround. Sue’s worked off her feet, mate, keeping us from going nuts.

Downstairs, nah, that’s not the retinals, they’re good lads mostly. It’s the other lot. Blimey, they’re worse than the prefrontals. Something comes in from the brainstem or amygdala, and it’s right lads, drop everything, jump to it, like it’s the bloody army. Mostly it’s a false alarm. Sue reckons nine out of ten times it wouldn’t do ‘em a bit of harm to wait a bit and ask nicely, but you can’t say so, they just scream even louder.

It’s not too bad, mate. I get a bit creaky at times, who doesn’t, but we manage, don’t we lads?

Touch of amyloid, I reckon. Slows me down a bit.

Yeah, course it’s a problem. If it builds up enough it’ll kill you. Nasty stuff, amyloid. But I reckon I’m good for a few years yet.

Everyone’s gotta die some time, mate. I’m lucky compared with some. In some of the departments upstairs there’s loads of neurons going off sick with amyloid poisoning, apparently. So Sue says. She hears stuff, Sue does. Very well-connected.

Yeah. You don’t come back from that kind of sickness.

Not so bad here, no. It’s a good department, the thalamus. We get wind of pretty much everything, and the work’s pretty constant. Keeps us busy.

I reckon that’s part of it. You sit idle, before you know it your synapses are dying off. See, without synapses, you can’t talk to no one. And I ask you, what’s the point of a neuron that can’t communicate?

Yeah, you don’t want to overdo it either. All things in moderation, mate.

Bored? Nah. We grumble, course we do, but none of us’d give it up, would we? It’s good work.

Don’t I ever feel like doing something else? Did you hear that, mates? You sound like Sue on a bad day, when she gets stressed. Blimey, it’s ‘What’s it all for?’ and ‘What’s the point?’ till the rest of us are shutting off transmission right, left and centre.

I know, love. You can’t help it. You do a great job, we all reckon you’re the best in the department, never mind the nucleus. Sorry, mate, what was that?

Course I could stop if I wanted to! That’s not the point; why would I want to? Let down all my mates? Someone would have to cover the extra inputs. Look at Fred there, he’s sweating ions like anything cos it’s all kicking off in our quadrant and his retinals are going ballistic. I couldn’t just say cheers and bugger off, now could I?

And I’d miss the company. Blimey, without their backchat I wouldn’t know where I was! Nah, mate, you can keep your freedom.

Yeah, so I’ll die in harness. What’s wrong with that? Like I said, everyone’s gotta go some time. Even if you do everything right, keep an eye on your proteins, make sure your DNA’s tidy, keep the glia sweet and all the rest of it, chances are you’ll get a blood vessel burst in the neighbourhood, or catch a sodding virus. What I’m saying is, some stuff you just can’t do a thing about. Anyway, I’d much rather go from a burst than from amyloid.

Slow and lingering, mate, and bloody painful. No thanks.

Bursts? They didn’t used to be, but from what I hear they’re getting commoner. There was one upstairs just the other day. Their local vessel got blocked up. That’s what triggers it, usually, unless there’s trouble among the epithelials.

You know. They man the blood vessels. Keep supplies flowing properly.

Fat deposit, they said. Horrible bloody great lumps. They get carried in with the food supply, and sometimes they’re too big, so they stick, and then stuff can’t get past.

I dunno why they let it through, mate, it don’t make sense to me neither, but it’s not my department.

Anyway, all the neurons downstream started yelling, cos of course they’re not getting enough supplies, are they? Meanwhile the blood pressure’s building up, and the epithelials are feeling the strain, so they’re yelling for the glia too …

Glia? Ain’t you met any glia yet? Sorry, mate, didn’t realise. Glia’s the cleaners, technicians, emergency services, that lot. Keep the place running, they do.

No, mate, we don’t have no hierarchies here. Up in prefrontal, they think they’re the masters of the bloody universe, they’ve got hierarchies all over the place. Silly bastards. Without the glia they wouldn’t last a day.

You’re not wrong. They’re well happy to lord it over the rest of us until something goes pear-shaped. Then it’s panic, and yell for the glia to sort it. You know how it is. And do the poor overworked buggers get any thanks? Down here, we say thank you when someone’s done us a favour.

Yeah, there’s a good feel to the place. I wouldn’t swap, not if you offered me a year’s supply of glucose. Anyway, where was I?

Oh yeah, the burst. Sue told us, she heard it from a friend who was on the edge of the death zone. It’s a nightmare. Everyone’s screaming, then they start shutting down from lack of fuel. The glia did their bloody best, but fat, you know, it’s nasty stuff. Pretty much impossible to shift when there’s a massive lump like that, there just ain’t time.

Before the blood pressure gets too much and the epithelials can’t cope, mate. Then you get a burst. Blood everywhere, neurons choking, everyone yelling for help, then it all goes quiet.

Yeah. They reckoned it was several thousand last time.

That’s nothing. You get a really big burst, it can take out millions.

Nah, we haven’t had anything like that yet. But it’s only a matter of time. Everyone’s getting on, you know. The epithelials aren’t as limber as they used to be, let’s face it, none of us are.

Stoic? I dunno about stoic. Don’t have much choice, do we?

Yeah yeah. That’s all very well, mate, but it’s not very realistic, if you don’t mind me saying. I’m not going to bloody emigrate, am I? Where would I find a job as good as this? I’d be lost without the work, mate, and that’s the truth.

It’s not a bad life. Yeah, we live on the edge. But so does everyone, when you think about it. That’s what Sue says, and I reckon she’s right.

Like I said, at least a burst’s quick. Not like amyloid. Bloody agony, that is. If my amyloid levels get too high, I’m telling you, I’m heading for the exit.

Apoptosis, mate. It’s a procedure we neurons have, for if it all gets too much.

Suicide, yeah, if you wanna call it that.

Don’t see why you’re shocked. You’re the one’s been banging on about freedom. What could be freer than choosing when to die, eh?

Look, mate, if you’ve had a good life, what’s the problem? I’ve worked hard, I’ve lived on good terms with my neighbours, I’ve done what I was put on earth to do. Far as I’m concerned, what diffs if we was all wiped out tomorrow?

Except I’d miss the chat. And the taste of real fresh oxygen.

Nothing like it, mate. Nothing like it.

Yeah? Well, you’d better head off then. Don’t wanna be late, not with that lot.

Been a pleasure. Not everyone makes it down here.

Yeah, let’s hope so. Years and years. You too.

Cheers, mate. Enjoy the rest of your tour.

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  1. For what it’s worth there is a book titled “Who’s Who of the Brain” – A guide to the inhabitants, where they live and what they do. Written by Kenneth Nunn, Tanya Hanstock & Bryan Lask. e.g. Lilly Listentale: the Temporal Lobes – lives in Uptown Cephalton. ……. It’s ‘novel’ but not a ‘novel’.

  2. I posted then I read the ‘conversation’ above. Rarely do I read a blog post word for word – this time I did. The outcome? A smile – as much in appreciation as in amusement, for the miracle between my ears.

    Thx

    • Hi Jean, I’m delighted you liked Alfie and friends, and many thanks for the reference, it sounds great, I’ll look it up.


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